Diospyros kaki Extract Inhibits Alkali Burn-Induced Corneal Neovascularization
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چکیده
منابع مشابه
Minocycline Inhibits Alkali Burn-Induced Corneal Neovascularization in Mice
The purpose of this study was to investigate the effects of minocycline on alkali burn-induced corneal neovascularization (CNV). A total of 105 mice treated with alkali burns were randomly divided into three groups to receive intraperitoneal injections of either phosphate buffered saline (PBS) or minocycline twice a day (60 mg/kg or 30 mg/kg) for 14 consecutive days. The area of CNV and corneal...
متن کاملPlasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization.
PURPOSE Plasminogen kringle 5 (K5) is a potent angiogenic inhibitor. The purpose of the present study was to evaluate the therapeutic effect of K5 on alkali-burn-induced corneal neovascularization (NV) and to investigate its mechanism of action. METHODS Corneal NV was induced in rabbits by NaOH. The rabbits received eye drops containing K5 or vehicle alone, four times per day. Corneal NV and ...
متن کاملTherapeutic Effects of Topical Netrin-4 Inhibits Corneal Neovascularization in Alkali-Burn Rats
Netrins are secreted molecules involved in axon guidance and angiogenesis. However, the role of netrins in the vasculature remains unclear. Netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. Previously, we found that netrin-1 acts as an anti-angiogenic factor in rats by inhibiting alkali burn-induced corneal neovascularization. Here, we further investigate the ef...
متن کاملInhibition of mouse alkali burn induced-corneal neovascularization by recombinant adenovirus encoding human vasohibin-1
PURPOSE To evaluate the activity of recombinant adenovirus encoding human vasohibin-1 (Ad-Vasohibin-1) on mouse corneal neovasularization induced by alkali burn. METHODS For the treatment group, 50 mice each received subconjunctival injection (5 microl) of 10(9) plaque forming units of replication-defective Ad-Vasohibin-1. Control group mice received the same dosage of blank adenoviral vector...
متن کاملComparison of genome-wide gene expression in suture- and alkali burn-induced murine corneal neovascularization
PURPOSE Suture placement and alkali burn to the cornea are often used to induce inflammatory corneal neovascularization (CorNV) models in animals. This study compares the changes in genome-wide gene expression under these two CorNV conditions in mice. METHODS CorNV were induced in Balb/c mice by three interrupted 10-0 sutures placed at sites about 1 mm from the corneal apex, or by alkali burn...
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ژورنال
عنوان ژورنال: Journal of Medicinal Food
سال: 2016
ISSN: 1096-620X,1557-7600
DOI: 10.1089/jmf.2014.3404